Endocrine Abstracts

Introduction: Acromegaly is usually caused by pituitary macroadenoma producing excess growth hormone. Treatment options include surgery to remove the tumor, medications, and radiation therapy.Case report: A 39-year-old woman has been referred to the endocrine clinic with suspected acromegaly in December 2019. Surgery for benign ovarian cyst, endometriosis, amenorrhoea, unsuccessful in vitro fertilisations were present in her medical history. She complain...

Background: Peripheral clocks are set by different nervous, hormonal and metabolic stimuli and regulate the circadian expression of several genes. It has been demonstrated that circadian oscillation of gene expression can be detected in various cell lines in vitro.Aim: To explore whether a peripheral clock could be induced in human adrenocortical cell line H295R and what are the effects of glucocorticoids on this clock system.<p class="abste...

Statins are effective treatment for the prevention of cardiovascular diseases and used extensively worldwide. However, adverse effects induced by statins are the major barrier of maximalising cardiovascular risk reduction. Hypothyroidism and administration of drugs metabolised on the same cytochrome P450 (CYPP450) pathways where statin biotransformation occurs represent a significant risk factor for statin induced adverse effects including myopathy. Simvastatin, atorvastatin a...

Vitamin D plays an important role in the adaptive and innate immunity besides its skeletal effects. Some autoimmune disease is associated with vitamin D deficiency highlighting its crucial involvement in the onset of autoimmune diseases. This study investigated the relationship between the vitamin D supply and the serum IL-6, IL-17A and antibody levels against thyroid peroxidase (TPO) and TSH receptor in autoimmune thyroid diseases. Serum IL-6, IL-17A and antibody levels again...

Introduction: Phenylketonuria (PKU) is a rare inherited metabolic disorder that leads to the toxic accumulation of phenylalanine (Phe) causing usually severe mental retardation and seizures. The basis of the lifelong therapy is low in natural-protein diet and Phe-free amino acid mixtures, that provide the daily necessary amino acids, vitamins and micronutrients, such as Iodine and Selenium. It is not well known, whether the adherence to the therapy can influence the thyroid fu...

Obesity is a major contributor to a range of metabolic disorders responsible for much of the medical morbidity and mortality. Increasing numbers of reports concerning not only obesity, but diabetes, hyperglycaemia and lipid dysregulation in patients treated with antipsychotics have raised concerns about a possible association between these metabolic effects and treatment with these medications. The objective of our study was to investigate the prevalence of obesity and other m...

Objectives: The use of levothyroxine (LT4) treatment aiming to improve fertility in euthyroid women with positive thyroid peroxidase antibodies (TPOAb), is not supported by the available evidence, however the extent to which this is applied in clinical practice is unknown. The aim of the study was to document the demographic, work-related characteristics, and therapeutic choices of European physicians in the case of euthyroid infertile women positive for TPOAb.<p class="ab...

Objectives: Some hypothyroid patients are critical of their care, although this appears to vary between countries. The quality of thyroid care delivered, and the perceived patient experience may be influenced by characteristics of specialists such as age, sex, experience, and workplace setting. Here, we aimed to explore geographical differences in thyroid specialist characteristics.Methods: THESIS is a large European questionnaire survey of thyroid speci...

Hereditary genetic variants are common among patients with endocrine tumours. Some specific clinical conditions are informative for certain monogenic syndromes (i.e., Carney complex, MEN1, MEN2, von Hippel Lindau syndrome) but manifestations characteristic for these syndromes occur more commonly as apparently sporadic. Other tumours, i.e., pheochromocytoma/paragangliomas (PPGL) are linked to multiple genes, hence a multigene approach in molecular genetic testing strategy is re...

Objective: MicroRNAs are short non-protein coding RNA molecules involved in the regulation of numerous homeostatic processes via modulating gene expression. There are some data that the expression of microRNA might be modulated by hormones, but the interaction of hormones and circulating microRNAs of adrenocortical origin is mostly unknown.Methods: The expression of six selected circulating microRNAs (hsa-miR-27a, hsa-miR-125b-2, hsa-miR-200b, hsa-miR-21...